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Golden bubbly casserole in a rectangular baking dish with green spinach peeking out, topped with melted cheese.

Spinach and Artichoke Chicken Casserole

Creamy, cheesy, and packed with tender chicken, this casserole is a cozy hug in a baking dish.

Total: 60 minPrep: 15 minCook: 45 min6 servingsDifficulty: Easy⭐ 4.7 (123+ ratings)$

Ingredients

Servings:

Steps

  1. 1 Preheat oven to 375°F.
  2. 2 Cook pasta according to package instructions; drain and set aside.
  3. 3 In a large bowl, combine cooked pasta, chicken, spinach, and artichokes.
  4. 4 In a separate bowl, mix sour cream, mayonnaise, garlic powder, oregano, black pepper, salt, and red pepper flakes if using.
  5. 5 Pour the sauce over the pasta mixture and stir until well combined.
  6. 6 Transfer mixture to a greased 9x13 inch baking dish.
  7. 7 Top with mozzarella and Parmesan cheeses.
  8. 8 Bake for 30-35 minutes, or until bubbly and cheese is melted and golden.
  9. 9 Let stand for 5 minutes before serving.

Equipment

Variations

Substitutions

Pairings

Nutrition

Calories: 450 kcal
Fat: 25g fat
Carbs: 25g carbohydrates
Protein: 28g protein
Fiber: 3g fiber
Sugar: 3g sugar
Sodium: 700mg sodium

Tips

Storage

Store leftovers in an airtight container in the fridge for up to 3 days. Reheat in a 350°F oven until warmed through.

Freezing: Freezes well for up to 2 months. Thaw overnight in the fridge and bake covered at 350°F for 45 minutes, then uncover and bake an additional 10-15 minutes.

Serving Suggestions

FAQ

Can I make this casserole ahead of time?

Absolutely! Prepare it up to the baking step, cover, and refrigerate for up to a day.

What can I use instead of mayonnaise?

Greek yogurt works well as a substitute for a healthier option.

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